Pae J, Schwan N., Ottino-Loffler B, DeWitt WS, Garg A, Bortolatto J, Vora AA, Shen J-J, Hobbs A, Castro TBR, Mesin L, Matsen FA IV, Meyer-Hermann M, Victora GD. Transient silencing of hypermutation preserves B cell affinity during clonal bursting. Nature. 2025 March 19; doi.org/10.1038/s41586-025-08687-8.

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Canesso MCC, Castro TBR, Sandra Nakandakari-Higa S, Lockhart A, Luehr J, Bortolatto J, Parsa R, Esterhazy D, Liu T-T, Murphy KM, Sonnenberg GF, Reis BS, Victora GD*, Mucida D*. Identification of antigen-presenting cell-T cell interactions driving immune responses to food. Science. 2024 Dec 19:eado5088; doi: 10.1126/science.ado5088. bioRxiv.

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Chudnovskiy A, Nakandakari-Higa S, Castro TBR, Cui A, Lin C-H, Sade-Feldman M, Phillips BK, Pae J, Mesin L, Bortolatto J, Schweitzer LD, Pasqual G, Lu L-F, Hacohen N, Victora GD. Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response. Sci Immunol. 2024 Oct 4;9(100):eadq8843. doi: 10.1126/sciimmunol.adq8843. pdf. bioRxiv.

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Schiepers A, van ’t Wout MFL, Hobbs A, Mesin L, Victora GD. Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers Immunity. 2024 Jul 9;57(7):1618-1628.e4. doi: 10.1016/j.immuni.2024.05.009. bioRxiv.

 

Nakandakari-Higa S, Canesso MCC*, Walker S*, van der Heide V, Chudnovskiy A, Kim D-Y, Bilanovic J, Jacobsen JT, Parigi M, Fiedorczuk K, Bilate AM, Fuchs E, Pasqual G, Mucida D, Kamphorst AO, Pritykin Y*, Victora GD*. Universal recording of immune cell interactions in vivo. Nature. 2024. doi: 10.1038/s41586-024-07134-4. pdf. bioRxiv.

 

Schiepers A, van 't Wout MFL, Greaney AJ, Zang T, Muramatsu H, Lin PJC, Tam YK, Mesin L, Starr TN, Bieniasz PD, Pardi N, Bloom JD, Victora GD. Molecular fate-mapping of serum antibody responses to repeat immunization. Nature. 2023 Mar;615(7952):482-489. doi: 10.1038/s41586-023-05715-3. pdf. bioRxiv.

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de Carvalho RVH*, Ersching J*, Barbulescu A*, Hobbs A, Castro TBR, Mesin L, Jacobsen JT, Phillips BK, Hoffman H-H, Parsa R, Canesso MCC, Nowosad CR, Feng A, Leist SR, Baric RS, Yang E, Utz PJ, Victora GD. Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell​. 2023 Jan 5;186(1):131-146.e13. doi: 10.1016/j.cell.2022.11.031. pdf

 

Jacobsen JT, Hu W, Castro TBR, Solem S, Galante A, Lin Z, Allon SJ, Mesin L, Bilate A, Schiepers A, Shalek AK, Rudensky A, Victora GD. Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science. 2021 Jul 16;373(6552):eabe5146. doi: 10.1126/science.abe5146.  pdf

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Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD. Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. J Exp Med. 2021 Apr 5;218(4):e20201699. doi: 10.1084/jem.20201699. bioRxiv.

 

Nowosad C*, Mesin L*, Castro TBR, Wichmann C, Donaldson GP, Araki T, Schiepers  A, Lockhart AAK,  Bilate AM, Mucida D*, Victora GD*. Tunable dynamics of B cell selection in gut germinal centers. Nature. 2020 Dec;588(7837):321-326. doi: 10.1038/s41586-020-2865-9. Epub 2020 Oct 28.

Mesin L*, Schiepers A*, Ersching J, Barbulescu A, Cavazzoni CB, Angelini A, Okada T, Kurosaki T, Victora GD. Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting. Cell. 2020 Jan 9;180(1):92-106.e11. doi: 10.1016/j.cell.2019.11.032

Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, Ellyard J, Shen Q, Robert PA, Cappello J, Vohra H, Zhang Y, Nowosad CR, Schiepers A, Corcoran LM, Toellner KM, Polo JM, Meyer-Hermann M, Victora GD, Vinuesa CG. Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity. 2019 Aug 20;51(2):337-350.e7. doi: 10.1016/j.immuni.2019.07.001. Epub 2019 Jul 30.

 

Jacobsen JT, Mesin L, Markoulaki S, Schiepers A, Cavazzoni CB, Bousbaine D, Jaenisch R, Victora GD. One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation. J Exp Med. 2018 Oct 1;215(10):2686-2695. doi: 10.1084/jem.20172064. bioRxiv.

Pasqual G, Chudnovskiy A, Tas JMJ, Agudelo M, Schweitzer LD, Cui A, Hacohen N, Victora GD. Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling. Nature. 2018 Jan 25;553(7689):496-500. doi: 10.1038/nature25442

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD. Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity. 2017 Jun 20;46(6):1045-1058.e6. doi: 10.1016/j.immuni.2017.06.005

Tas JMJ,* Mesin L,* Pasqual G, Targ S, Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M, Victora GD. Visualizing antibody affinity maturation in germinal centers. Science, 18 Feb 2016 (7689):. doi: 10.1126/science.aad3439

Shulman Z, Gitlin AD, Targ S, Jankovic M, Pasqual G, Nussenzweig MC*, Victora GD*. In vivo dynamics of Tfh cells in Germinal Centers. Science. Aug 9;341(6146):673-7. doi: 10.1126/science.1241680

Dominguez-Sola D*, Victora GD*, Ying CY, Phan RT, Saito M, Nussenzweig MC, Dalla-Favera R.The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol. 2012 Nov;13(11):1083-91. doi: 10.1038/ni.2428

Victora GD*, Dominguez-Sola D*, Deroubaix S, Holmes AB, Dalla-Favera R, Nussenzweig MC. Identification of human germinal center light and dark zone cells and their relationship to human B cell lymphomas. Blood. 2012 Sep 13;120(11):2240-8. doi: 10.1182/blood-2012-03-415380

Schwickert TA*, Victora GD*, Fooksman DR, Kamphorst AO, Mugnier MR, Gitlin AD, Dustin ML, Nussenzweig MC. A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med. 2011 Jun 6;208(6):1243-52. doi: 10.1084/jem.20102477

Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010 Nov 12;143(4):592-605. doi: 10.1016/j.cell.2010.10.032

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